31P NMR spectroscopy of in vivo tumors

A probe, suitable for any wide-bore NMR spectrometer, was constructed for monitoring high-resolution spectra of in vivo subcutaneously implanted tumors in mice. Preliminary studies of a variety of murine tumors (MOPC 104E myeloma, Dunn osteosarcoma, colon-26, ovarian M5, and mammary adenocarcinoma a...

Full description

Saved in:
Bibliographic Details
Published in:Journal of magnetic resonance (1969) 1982-09, Vol.49 (2), p.271-286
Main Authors: Ng, T.C, Evanochko, W.T, Hiramoto, R.N, Ghanta, V.K, Lilly, M.B, Lawson, A.J, Corbett, T.H, Durant, J.R, Glickson, J.D
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A probe, suitable for any wide-bore NMR spectrometer, was constructed for monitoring high-resolution spectra of in vivo subcutaneously implanted tumors in mice. Preliminary studies of a variety of murine tumors (MOPC 104E myeloma, Dunn osteosarcoma, colon-26, ovarian M5, and mammary adenocarcinoma as well as human colon, mammary, and lung tumors in athymic mice) indicate that the 31P NMR spectrum is a sensitive monitor of progressive metabolic changes that occur during untreated tumor growth and an early indicator of tumor response to chemotherapy, hyperthermia, and X radiation. Response to each of these therapeutic modalities is accompanied by distinctly different spectral changes.
ISSN:0022-2364
1557-8968
DOI:10.1016/0022-2364(82)90190-1