A pulse sequence for simplifying hydrogen NMR spectra of biological tissues

1H NMR studies of many mammalian tissues are complicated by the presence of large lipid resonances that obscure much of the spectrum. In this communication a simple spin-echo homonuclear double-resonance difference sequence was used to separate the resonances of alanine, lactate, β-hydroxybutyrate,...

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Bibliographic Details
Published in:Journal of magnetic resonance (1969) 1984-01, Vol.60 (3), p.430-436
Main Authors: Rothman, D.L, Arias-Mendoza, F, Shulman, G.I, Shulman, R.G
Format: Article
Language:English
Subjects:
Biological and medical sciences
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Miscellaneous. Technology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
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Summary:1H NMR studies of many mammalian tissues are complicated by the presence of large lipid resonances that obscure much of the spectrum. In this communication a simple spin-echo homonuclear double-resonance difference sequence was used to separate the resonances of alanine, lactate, β-hydroxybutyrate, glutamate, and glutamine from the lipid resonances which overlap them in excised rat leg muscle and heart, and in an excised mouse liver which had been perfused with [3- 13C]alanine.
ISSN:0022-2364
1557-8968
DOI:10.1016/0022-2364(84)90054-4