Intestinal rotation in experimental congenital diaphragmatic hernia

This study examines whether experimental congenital diaphragmatic hernia (CDH) induced by nitrofen in rats is accompanied by intestinal malrotation similar to that observed in the human condition. Time-dated pregnant rats were fed 100 mg of nitrofen on day 9.5 of gestation, and fetuses were examined...

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Bibliographic Details
Published in:Journal of pediatric surgery 1995-10, Vol.30 (10), p.1457-1462
Main Authors: Baoquan, Qi, Diez-Pardo, Juan A, Tovar, Juan A
Format: Article
Language:English
Subjects:
Abnormalities, Drug-Induced - etiology
Animals
Biological and medical sciences
Fetal Diseases - chemically induced
Hernia, Diaphragmatic - chemically induced
Hernias, Diaphragmatic, Congenital
Intestines - abnormalities
Lung - abnormalities
Medical sciences
Phenyl Ethers
Pneumology
Rats
Respiratory system : syndromes and miscellaneous diseases
Torsion Abnormality - congenital
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Summary:This study examines whether experimental congenital diaphragmatic hernia (CDH) induced by nitrofen in rats is accompanied by intestinal malrotation similar to that observed in the human condition. Time-dated pregnant rats were fed 100 mg of nitrofen on day 9.5 of gestation, and fetuses were examined on days 17, 19, and 21. Body weight, lung weight, grade of bowel herniation into the umbilical cord and grade of intestinal malrotation were compared with those of age-matched controls. Body and lung weights were significantly lower in nitrofen-exposed rats on days 17, 19, and 21. The umbilical hernia persisted on day 17 in 100% of experimental animals and 66% of controls ( P
ISSN:0022-3468
1531-5037
DOI:10.1016/0022-3468(95)90407-7