Thin-layer chromatography of fluoropyrimidines

The recent interest in fluoropyrimidines as agents in cancer therapy and the lack of published data concerning their chromatographic properties prompted a study of these and related compounds by thin-layer chromatography. Good separations have been achieved on plates coated with silica gel GF. By us...

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Bibliographic Details
Published in:Microchemical journal 1964, Vol.8 (1), p.15-22
Main Authors: Hawrylyshyn, M., Senkowski, B.Z., Wollish, E.G.
Format: Article
Language:English
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Summary:The recent interest in fluoropyrimidines as agents in cancer therapy and the lack of published data concerning their chromatographic properties prompted a study of these and related compounds by thin-layer chromatography. Good separations have been achieved on plates coated with silica gel GF. By using a two-dimensional technique, a solvent system was employed consisting of ethyl acetate:acetone:water in the ratio 70:40:10, followed by chromatography with a solvent containing ethyl acetate:methanol:conc. ammonium hydroxide, 75:25:1. A number of other solvent systems and the R ƒ values obtained with their use have been tabulated. These data should be helpful for the study of the chemical or metabolic reaction products of these and related fluoro compounds.
ISSN:0026-265X
1095-9149
DOI:10.1016/0026-265X(64)90006-2