Polarographic behavior and determination of Flumequine

Flumequine was found to be reduced at the dropping mercury electrode in Britton-Robinson buffer containing methanol as a solubilizer, over the pH range 5–10. A well-defined cathodic wave was produced over this entire range. The wave was characterized as being diffusion-controlled, although adsorptio...

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Bibliographic Details
Published in:Microchemical journal 1990-12, Vol.42 (3), p.300-305
Main Authors: Belal, F., El-Din, M.Sharaf
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
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Summary:Flumequine was found to be reduced at the dropping mercury electrode in Britton-Robinson buffer containing methanol as a solubilizer, over the pH range 5–10. A well-defined cathodic wave was produced over this entire range. The wave was characterized as being diffusion-controlled, although adsorption phenomena played a limited role in the reduction process. The proposed method was applied to the determination of Flumequine in tablets, and the results were satisfactorily accurate and precise.
ISSN:0026-265X
1095-9149
DOI:10.1016/0026-265X(90)90059-E