Desorption chemical ionization and field desorption mass spectrometric analysis of antitumor Catharanthus (Vinca) alkaloids

Antitumor Catharanthus (Vinca) alkaloids, vinblastine and vincristine, and their chemically modified derivatives N-deformylvincristine, N-deformyl-4-deacetylvincristine, vindesine, 4-deacetylvinblastine, and 4-deacetylvincristine, after purification by high-pressure liquid chromatography were analyz...

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Bibliographic Details
Published in:Microchemical journal 1990-04, Vol.41 (2), p.183-190
Main Authors: Thimmaiah, K.N., Thomas, M.J., Sethi, V.S., Gowda, N.M.Made
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
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Summary:Antitumor Catharanthus (Vinca) alkaloids, vinblastine and vincristine, and their chemically modified derivatives N-deformylvincristine, N-deformyl-4-deacetylvincristine, vindesine, 4-deacetylvinblastine, and 4-deacetylvincristine, after purification by high-pressure liquid chromatography were analyzed using the soft ionization technique of desorption chemical ionization mass spectrometry or field desorption mass spectrometry. The dominant signal from the free bases by these techniques was their respective protonated molecular ion. These studies suggest that these techniques can be conveniently applied for characterization of the metabolites and/or in vitro degradation products of the antitumor alkaloids.
ISSN:0026-265X
1095-9149
DOI:10.1016/0026-265X(90)90117-N