Effect of electrostatic and hydrophobic interactions between comb-like polycations and lipids on the change in permeability of lipids at different pH values

The effect of homologous comb-like polycations, copolymers of N-vinylpyrrolidone and N-vinylalkylamines on the permeability of negatively charged dipalmitoylphospatidylcholine liposomes from dipalmitoylphosphatidylcholine containing dipalmitoylphosphatide acid are studied at various solution pH valu...

Full description

Saved in:
Bibliographic Details
Published in:Polymer science USSR 1990, Vol.32 (12), p.2482-2487
Main Authors: Maksimenko, O.O, Fel'dshtein, M.M, Panarin, Ye.F, Torchilin, V.P, Vasil'ev, A.Ye, Plate, N.A
Format: Article
Language:English
Subjects:
Applied sciences
Exact sciences and technology
Organic polymers
Physicochemistry of polymers
Properties and characterization
Thermal and thermodynamic properties
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of homologous comb-like polycations, copolymers of N-vinylpyrrolidone and N-vinylalkylamines on the permeability of negatively charged dipalmitoylphospatidylcholine liposomes from dipalmitoylphosphatidylcholine containing dipalmitoylphosphatide acid are studied at various solution pH values. The maximum increase in liposome permeability for the 6-carboxy-fluorescein and calceine markers is observed with the copolymer of N-vinyloctylamine over a narrow pH range close to 7.0. The peak-like increase in the permeability of liposomes in a neutral media in regions of neutral pH requires a balance of the electrostatic and hydrophobic interactions between the polycations and the lipid double layer. An increase in the contribution of one of these interactions results in a loss of the significant, and peak-like change in permeability of liposomes with change in pH.
ISSN:0032-3950
1878-268X
DOI:10.1016/0032-3950(90)90423-4