New fluorine-containing building blocks from trifluoroethanol. 1

A new fluorine containing acyl anion equivalent 1,1-difluoro-2-lithio-2-[(methoxyethoxy)methoxy]ethene 12 has been prepared from trifluoroethanol and trapped with a number of electrophiles in good yield. Effective electrophiles included Group(IV) halides and carbonyl compounds. Attempts to alkylate...

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Bibliographic Details
Published in:Tetrahedron 1995-08, Vol.51 (33), p.9201-9216
Main Authors: Patel, Sunita T., Percy, Jonathan M., Wilkes, Robin D.
Format: Article
Language:English
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Summary:A new fluorine containing acyl anion equivalent 1,1-difluoro-2-lithio-2-[(methoxyethoxy)methoxy]ethene 12 has been prepared from trifluoroethanol and trapped with a number of electrophiles in good yield. Effective electrophiles included Group(IV) halides and carbonyl compounds. Attempts to alkylate using iodomethane were unsuccessful.
ISSN:0040-4020
1464-5416
DOI:10.1016/0040-4020(95)00525-D