Synthesis of 20-fluorovitamin D analogues

A synthetic approach to novel 20-fluorovitamin D analogues is described. Introduction of fluorine has been performed by electrophilic fluorination followed by elaboration of biologically interesting side chain substructures.

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Bibliographic Details
Published in:Tetrahedron 1995-08, Vol.51 (35), p.9543-9550
Main Authors: Schwarz, Katica, Neef, Günter, Kirsch, Gerald, Müller-Fahrnow, Anke, Steinmeyer, Andreas
Format: Article
Language:English
Subjects:
20-fluoro substitution
calcipotriol derivatives
calcitriol analogues
electrophilic fluorination
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Description
Summary:A synthetic approach to novel 20-fluorovitamin D analogues is described. Introduction of fluorine has been performed by electrophilic fluorination followed by elaboration of biologically interesting side chain substructures.
ISSN:0040-4020
1464-5416
DOI:10.1016/0040-4020(95)00612-C