Solid phase synthesis of alkylphosphonopeptides

The solid phase assembly of alkylphosphonylated peptides 3a,b using the readily available new phosphonylating reagents p-methoxybenzyl N,N-diisopropylaminomethylphosphonamidite ( 9a) and its octyl analogue ( 9c) is described. The solid phase assembly of alkylphosphonylated peptides 1a,b using readil...

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Bibliographic Details
Published in:Tetrahedron 1996-02, Vol.52 (6), p.2103-2112
Main Authors: Wijkmans, Jac C.H.M., Meeuwenoord, Nico J., Bloemhoff, Wim, van der Marel, Gijs A., van Boom, Jacques H.
Format: Article
Language:English
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Summary:The solid phase assembly of alkylphosphonylated peptides 3a,b using the readily available new phosphonylating reagents p-methoxybenzyl N,N-diisopropylaminomethylphosphonamidite ( 9a) and its octyl analogue ( 9c) is described. The solid phase assembly of alkylphosphonylated peptides 1a,b using readily available new p-methoxybenzyl protected phosphonylating reagents is described.
ISSN:0040-4020
1464-5416
DOI:10.1016/0040-4020(95)01027-0