Assignment of the 1H NMR spectrum and solution conformation of the antitumour antibiotic ditrisarubicin B

Complete assignment of the 1H NMR spectrum of ditrisarubicin B, a member of the anthracycline antitumour antibiotics, in acetonitrile is reported. The two trisaccharide chains are highly structured and their conformation supports their role as preorganised DNA minor groove binders which bind to DNA...

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Published in:Tetrahedron 1996-04, Vol.52 (15), p.5617-5624
Main Authors: Mackay, Joel P., Shelton, Cathryn J., Harding, Margaret M.
Format: Article
Language:English
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Summary:Complete assignment of the 1H NMR spectrum of ditrisarubicin B, a member of the anthracycline antitumour antibiotics, in acetonitrile is reported. The two trisaccharide chains are highly structured and their conformation supports their role as preorganised DNA minor groove binders which bind to DNA on intercalation of the tetracyclic chromophore. Cathryn J. Shelton and Margaret M. Harding, School of Chemistry, University of Sydney, N.S.W., 2006, Australia
ISSN:0040-4020
1464-5416
DOI:10.1016/0040-4020(96)00198-6