New procedures for the synthesis of heterocyclic substituted and 2,4-difunctionalized pyrimidines

N-Tosyl-2- and -3-acetylpyrrols 1 or N-tosyl-2-pyrrolidone 5 were condensed with cyano compounds in the presence of triflic anhydride (Tf 2O) to yield heteroarylpyrimidines. 2,4-Difunctionalized pyrimidines were obtained by reaction of the corresponding 2,4-bis(methylsulfonyl)pyrimidines with nucleo...

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Bibliographic Details
Published in:Tetrahedron 1996-06, Vol.52 (23), p.7973-7982
Main Authors: Martínez, Antonio García, Fernández, Antonio Herrera, Jiménez, Florencio Moreno, Muñoz Martínez, Pablo J, Martín, Cristina Alonso, Subramanian, Laksminarayanapuran R
Format: Article
Language:English
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Summary:N-Tosyl-2- and -3-acetylpyrrols 1 or N-tosyl-2-pyrrolidone 5 were condensed with cyano compounds in the presence of triflic anhydride (Tf 2O) to yield heteroarylpyrimidines. 2,4-Difunctionalized pyrimidines were obtained by reaction of the corresponding 2,4-bis(methylsulfonyl)pyrimidines with nucleophiles. Graphic
ISSN:0040-4020
1464-5416
DOI:10.1016/0040-4020(96)00368-7