Multiple solid phase synthesis via Fmoc-amino acid fluorides

In addition to displaying high reactivity. Fmoc-amino acid fluorides are shown to be highly soluble and stable for extended periods in organic solvents such as DMF and therefore to be recommended for use in Multiple Peptide Synthesis. A series of analogs of alamethicin and a partial sequence (22 ami...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 1995-02, Vol.36 (8), p.1247-1250
Main Authors: Wenschuh, Holger, Beyermann, Michael, Rothemund, Sven, Carpino, Louis A., Bienert, Michael
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In addition to displaying high reactivity. Fmoc-amino acid fluorides are shown to be highly soluble and stable for extended periods in organic solvents such as DMF and therefore to be recommended for use in Multiple Peptide Synthesis. A series of analogs of alamethicin and a partial sequence (22 amino acids) of the CNG-channel forming protein BOVTESTIS have been assembled with excellent results. In addition to displaying high reactivity, Fmoc-amino acid fluorides are shown to be highly soluble and stable for extended periods in organic solvents such as DMF and therefore to be recommended for use in Multiple Peptide Synthesis. A series of analogs of alamethicin and a partial sequence (22 amino acids) of the CNG-channel forming protein BOVTESTIS have been assembled with excellent results.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(94)02487-V