Synthesis and oxidative cleavage of the major equilibrium products of ascomycin and FK 506

Ascomycin and FK 506 are converted into the 9-ketal isomers in high yields by simple treatment with Lewis acids. The structure of the 9-ketal isomer was confirmed by oxidative cleavage. Graphic

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Bibliographic Details
Published in:Tetrahedron letters 1995-03, Vol.36 (13), p.2231-2234
Main Authors: Baumann, K, Oberhauser, B, Grassberger, M.A, Haidl, G, Schulz, G
Format: Article
Language:English
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Description
Summary:Ascomycin and FK 506 are converted into the 9-ketal isomers in high yields by simple treatment with Lewis acids. The structure of the 9-ketal isomer was confirmed by oxidative cleavage. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(95)00220-7