Synthesis of 4-(3-Indolyl)-oxazol-2-one via electrochemical processes

The synthesis of 4-(3-indolyl)-oxazol-2-one including two electrochemical pathways is described. This compound, possessing both indole and oxazol-2-one moieties is expected to be an efficient protein kinase C inhibitor and to exhibit a vasorelaxant effect on smooth muscle. The synthesis of 4-(3-indo...

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Bibliographic Details
Published in:Tetrahedron letters 1995-04, Vol.36 (14), p.2479-2482
Main Authors: Pereira, Elisabète Rodrigues, Spessel, Valérie, Prudhomme, Michelle, Martre, Anne-Marie, Mousset, Guy
Format: Article
Language:English
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Summary:The synthesis of 4-(3-indolyl)-oxazol-2-one including two electrochemical pathways is described. This compound, possessing both indole and oxazol-2-one moieties is expected to be an efficient protein kinase C inhibitor and to exhibit a vasorelaxant effect on smooth muscle. The synthesis of 4-(3-indolyl)-oxazol-2-one is described. This compound is expected to be an efficient protein kinase C inhibitor and a vascular smooth muscle relaxant.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(95)00287-1