Azoester compounds for inducing DNA cleavage under physiological conditions

It is demonstrated that azoester compounds are suitable for inducing DNA cleavage under physiological conditions. In particular, ethyl phenydiazenecarboxylate 1 and potassium phenyldiazenecarboxylate 2 have been shown to cleave ΦX174 supercoiled DNA in aqueous buffers of pH=7.2 and 5..2, respectivel...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 1995-05, Vol.36 (18), p.3123-3126
Main Authors: Jebaratnam, David J., Kugabalasooriar, S., Chen, Hang, Arya, Dev P.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It is demonstrated that azoester compounds are suitable for inducing DNA cleavage under physiological conditions. In particular, ethyl phenydiazenecarboxylate 1 and potassium phenyldiazenecarboxylate 2 have been shown to cleave ΦX174 supercoiled DNA in aqueous buffers of pH=7.2 and 5..2, respectively. It is demonstrated that azoester derivatives 1 and 2 are suitable for inducing DNA cleavage under physiological conditions.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(95)00480-Z