Synthesis of 5,6-difluoroarachidonic acid, a potential inhibitor of 5-lipoxygenase

The synthesis of 5,6-difluoroarachidonic acid 1 is described. The vicinal difluorinated double bond was prepared from the α-phenylthio-β-ketoester 4. The synthesis of 5,6-difluoroarachidonic acid 1 is described. The vicinal difluorinated double bond was prepared from the α-arylthio-β-ketoester 4....

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Bibliographic Details
Published in:Tetrahedron letters 1996-07, Vol.37 (28), p.4941-4944
Main Authors: Bildstein, Sylvia, Ducep, Jean-Bernard, Jacobi, Detlef, Zimmermann, Pascale
Format: Article
Language:English
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Summary:The synthesis of 5,6-difluoroarachidonic acid 1 is described. The vicinal difluorinated double bond was prepared from the α-phenylthio-β-ketoester 4. The synthesis of 5,6-difluoroarachidonic acid 1 is described. The vicinal difluorinated double bond was prepared from the α-arylthio-β-ketoester 4.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(96)00976-8