Facile synthesis of lysophospholipids containing unsaturated fatty acid chains

The efficient synthesis of polyunsaturated phospholipids is challenging due to the sensitivity of the unsaturated moiety to the conditions employed in phosphate ester deprotection. We discuss here three independent methods that resolve this issue and enable the synthesis of a series of unsaturated l...

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Bibliographic Details
Published in:Tetrahedron letters 1996-10, Vol.37 (44), p.7871-7874
Main Authors: Hopper, Darrin W., Catalano, John G., Macdonald, Timothy L.
Format: Article
Language:English
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Summary:The efficient synthesis of polyunsaturated phospholipids is challenging due to the sensitivity of the unsaturated moiety to the conditions employed in phosphate ester deprotection. We discuss here three independent methods that resolve this issue and enable the synthesis of a series of unsaturated lysophosphatidic acid mimics for the development of a more comprehensive understanding of the structure-activity relationship in this series. Methods are described for the efficient synthesis of unsaturated lysophosphatidic acid derivatives and mimics.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(96)01802-3