Effect of aspirin-dipyridamole and heparin and their combination on venous thrombosis in hypercoagulable or thrombotic animals

• Published in: Thrombosis research 1996-06, Vol.82 (6), p.479-483
• Main Authors: Iomhair, Maura Mhic, Lavelle, S.M.
• Format: Article
• Language: English
• Subjects: Animals; Aspirin - administration & dosage; aspirin/dipyridamole; Biological and medical sciences; Blood Coagulation - drug effects; Blood. Blood coagulation. Reticuloendothelial system; Dipyridamole - administration & dosage; Drug Combinations; Drug Therapy, Combination; EACA; ellagic acid; Ellagic Acid - toxicity; Female; heparin; Heparin - administration & dosage; hypercoagulable; Infusions, Intravenous; Male; Medical sciences; Pharmacology. Drug treatments; Platelet Aggregation Inhibitors - administration & dosage; Rats; Rats, Sprague-Dawley; Thrombosis - blood; Thrombosis - chemically induced; Thrombosis - drug therapy; Vena Cava, Inferior - pathology
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/0049-3848(96)00098-9

Epsilon-amino-caproic acid (EACA) induces a clinically-useful anti-haemorrhagic, mildly thrombotic state while ellagic acid (EA) induces a severe hypercoagulable one. Reversal of these states may on occasion by necessary. The effectiveness of the antiplatelet drugs, aspirin and dipyridamole ( ASA D ), in reducing thrombus weight was studied in normocoagulable animals and animals made hypercoagulable with EACA (333mg/kg) or EA (1.2mg/kg). Heparin (114iu/kg) was tested in the EACA group, both alone and in combination with ASA D . Thrombogenicity was measured by weight formed on intravenous platinum wire in one hour. In normocoagulable animals, ASA D reduced thrombus by 32%. Ellagic acid trebled mean thrombus weight and ASA D reduced this by 49%, but did not restore normality. EACA increased mean thrombosis by one sixth. Treatment with heparin reduced this by 48% to a level well below that of untreated animals. Addition of a single dose of aspirin/dipyridamole to the heparin regime, reduced thrombosis by a further 31%, reaching to 21% of control thrombus. The results were statistically significant. Kaolin-activated blood clotting time was shortened by EA, but EACA had little effect on it, while ASA D slightly and heparin markedly lengthened it.