Renal cortical mercury levels associated with experimental amalgam tattoos: effects of particle size and amount of implanted material

Powdered dental amalgam that had passed through either a 106 μm or a 45 μm sieve was implanted subcutaneously in guinea pigs for periods of up to 2 yr. The renal cortical mercury levels associated with the 106 μm material were on average 16% of those produced by the 45 μm material. A reduction in th...

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Bibliographic Details
Published in:Biomaterials 1987-09, Vol.8 (5), p.401-403
Main Authors: Eley, B.M., Cox, S.W.
Format: Article
Language:English
Subjects:
amalgam tattoo
Animals
dental amalgam
Dental Amalgam - adverse effects
Dentistry
Female
Guinea Pigs
Kidney Cortex - analysis
kidneys
mercury
Mercury - analysis
Particle Size
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Summary:Powdered dental amalgam that had passed through either a 106 μm or a 45 μm sieve was implanted subcutaneously in guinea pigs for periods of up to 2 yr. The renal cortical mercury levels associated with the 106 μm material were on average 16% of those produced by the 45 μm material. A reduction in the amount of 45 μm powder implanted, by a factor of 75%, resulted in a fall of only 27% in renal mercury concentrations. The marked effect of particle size on mercury release may be explained by the large increase in the proportion of implanted material that was degraded within phagocytic cells in the local lesions.
ISSN:0142-9612
1878-5905
DOI:10.1016/0142-9612(87)90013-5