Antibacterial activity and mutagenicity studies of water-soluble phosphazene high polymers

Eight water-soluble phosphazene high polymers, [NPR 2] n ( R, organic, water-solubilizing side-group; n, approx: 15 000) and the small-molecule counterparts of the polymers were examined for antibacterial activity against six different strains of bacteria ( Escherichia coli, Salmonella typhimurium (...

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Bibliographic Details
Published in:Biomaterials 1992, Vol.13 (12), p.857-862
Main Authors: Allcock, Harry R, Pucher, Shawn R, Fitzpatrick, Richard J, Rashid, Kamal
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
antibacterial activity
Aziridines - pharmacology
Bacillus subtilis - drug effects
Bacteria - drug effects
Biological and medical sciences
Enterobacteriaceae - drug effects
Enterococcus faecalis - drug effects
Hydrogels
Medical sciences
Microbial Sensitivity Tests
Molecular Weight
mutagenicity
Mutagenicity Tests
Mutagens
Polymers
polyphosphazenes
Pseudomonas aeruginosa - drug effects
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Solubility
Technology. Biomaterials. Equipments. Material. Instrumentation
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Summary:Eight water-soluble phosphazene high polymers, [NPR 2] n ( R, organic, water-solubilizing side-group; n, approx: 15 000) and the small-molecule counterparts of the polymers were examined for antibacterial activity against six different strains of bacteria ( Escherichia coli, Salmonella typhimurium (TA 100), Salmonella pullorum, Streptococcus faecalis. Bacillus subtilis and Pseudomonas aeruginosa). Antibacterial testing was carried out by measuring zones of inhibition and changes in solution turbidity over time. In addition, the antibacterial activity of the surfaces of cross-linked poly[di(methoxyethoxyethoxy)phosphazene] (MEEP) hydrogels were investigated. A number of the high polymers, as well as the MEEP hydrogels, impeded bacterial growth. Only E. coli was unaffected by the phosphazenes. A possible explanation for the antibacterial character of the polymers is presented. The same compounds were monitored for potential mutagenic activity using the Salmonella typhimurium tester strains TA 100 and TA 98. None of the high polymers or their small-molecule analogues showed mutagenic activity in either strain of Salmonella at the concentrations tested. The use of these materials as coatings for artificial implants is discussed.
ISSN:0142-9612
1878-5905
DOI:10.1016/0142-9612(92)90179-R