Physico-chemical studies on di-iodotyrosine dextran

Dextran is currently being considered as a carrier biopolymer system for drug targeting. Di-iodotyrosine (DIT), and its radioactive derivative are useful markers for identifying the in-vivo route of these substrates. The performance of these substances in vivo is closely linked to their physico-chem...

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Bibliographic Details
Published in:Carbohydrate polymers 1992, Vol.18 (4), p.289-294
Main Authors: Errington, Neil, Harding, Stephen E., Illum, Lisbeth, Schacht, Etienne H.
Format: Article
Language:English
Subjects:
Applied sciences
Exact sciences and technology
Natural polymers
Physicochemistry of polymers
Starch and polysaccharides
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Summary:Dextran is currently being considered as a carrier biopolymer system for drug targeting. Di-iodotyrosine (DIT), and its radioactive derivative are useful markers for identifying the in-vivo route of these substrates. The performance of these substances in vivo is closely linked to their physico-chemical properties in solution. These properties have been investigated on a series of gel permeation chromatography fractionated DIT-dextrans using a combination of sedimentation, viscometric and laser-light scattering techniques. Weight average molecular weights, M w, from sedimentation equilibrium and light scattering range from 0·0195 to 0·054 × 10 6. Double logarithmic representations of M w versus sedimentation coefficient, s o 20.w, and intrinsic viscosity [η] suggest that these labelled dextrans have a more compact conformation in solution than do their unlabelled analogues — which behave as random coils. The implications of this for drug delivery are indicated.
ISSN:0144-8617
1879-1344
DOI:10.1016/0144-8617(92)90094-7