Drug interactions in transplantation

Cyclosporine, tacrolimus, and mycophenolate are selective immunosuppressive agents commonly prescribed to prevent organ rejection. Drug interactions that increase their blood levels could expose transplant recipients to serious side effects, while drug interactions that decrease their blood levels m...

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Bibliographic Details
Published in:Clinical Therapeutics 1995-11, Vol.17 (6), p.1043-1061
Main Author: Seifeldin, Raafat
Format: Article
Language:English
Subjects:
Cyclosporine - metabolism
Cyclosporine - pharmacokinetics
Cytochrome P-450 Enzyme System - classification
Cytochrome P-450 Enzyme System - metabolism
Drug Interactions
Immunosuppressive Agents - metabolism
Immunosuppressive Agents - pharmacokinetics
Isoenzymes - classification
Isoenzymes - metabolism
Mycophenolic Acid - analogs & derivatives
Mycophenolic Acid - metabolism
Mycophenolic Acid - pharmacokinetics
Organ Transplantation
Tacrolimus - metabolism
Tacrolimus - pharmacokinetics
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Summary:Cyclosporine, tacrolimus, and mycophenolate are selective immunosuppressive agents commonly prescribed to prevent organ rejection. Drug interactions that increase their blood levels could expose transplant recipients to serious side effects, while drug interactions that decrease their blood levels may cause rejection episodes as a result of inadequate immunosuppression. Cyclosporine and tacrolimus are metabolized by the cytochrome P-450 enzyme system. Drugs that induce, inhibit, or compete for the same cytochrome P-450 enzyme could affect blood levels of these immunosuppressive agents.
ISSN:0149-2918
1879-114X
DOI:10.1016/0149-2918(95)80084-0