Effect of lithium carbonate therapy on thyroid immune status in manic depressive patients: A prospective study

Serum thyroid autoantibodies to thyroglobulin (TG) and thyroid microsomes (M) were measured by ELISA prospectively in 37 manic depressive patients prior to receiving lithium carbonate and during therapy with this drug for a mean of 16.2 months. They were also measured once in 27 normal subjects and...

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Bibliographic Details
Published in:Journal of affective disorders 1986-09, Vol.11 (2), p.155-160
Main Authors: Lazarus, John H., McGregor, Alan M., Ludgate, Marion, Darke, Chris, Creagh, Fionula M., Kingswood, Chris J.
Format: Article
Language:English
Subjects:
Adult
Aged
Autoantibodies - analysis
Biological and medical sciences
Bipolar Disorder - drug therapy
Female
Humans
Lithium - adverse effects
Lithium Carbonate
Lithium carbonate - Thyroid immune status - Manic depressive patients - Prospective study
Longitudinal Studies
Male
Medical sciences
Microsomes - immunology
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
Prospective Studies
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Thyroglobulin - immunology
Thyroid Gland - immunology
Thyroiditis, Autoimmune - etiology
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Summary:Serum thyroid autoantibodies to thyroglobulin (TG) and thyroid microsomes (M) were measured by ELISA prospectively in 37 manic depressive patients prior to receiving lithium carbonate and during therapy with this drug for a mean of 16.2 months. They were also measured once in 27 normal subjects and several times in five psychiatric patients not receiving lithium. Sixteen patients (43%) had either thyroglobulin, microsomal antibodies or both before receiving lithium therapy. During therapy significant fluctuations in antibody titre, both upwards and downwards were observed in ten out of 12 patients with M antibodies and in nine out of 11 with TG antibodies. The fluctuations in antibody titre are consistent with an immunomodulatory effect of lithium as has been shown in animal studies. It is suggested that psychiatric patients should have thyroid antibodies measured routinely before and during lithium therapy.
ISSN:0165-0327
1573-2517
DOI:10.1016/0165-0327(86)90023-6