Fluoxetine vs. clomipramine in depressed patients: a controlled multicentre trial

A sample of 120 patients, all of whom met DSM-III criteria for major unipolar depressive disorder, were randomly allocated to two treatment groups. Sixty patients were treated with fluoxetine and 60 with clomipramine during a 6-week period. No significant difference was found in antidepressant effic...

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Bibliographic Details
Published in:Journal of affective disorders 1991-07, Vol.22 (3), p.119-124
Main Authors: Noguera, Ramon, Altuna, Rosario, Alvarez, Enrique, Ayuso, Jose L., Casais, Leonardo, Udina, Claudia
Format: Article
Language:English
Subjects:
Adult
Aged
Antidepressant effect
Biological and medical sciences
Clomipramine - adverse effects
Clomipramine - therapeutic use
Depressive Disorder - drug therapy
Depressive Disorder - psychology
Double-Blind Method
Female
Fluoxetine - adverse effects
Fluoxetine - therapeutic use
Fluoxetine vs. clomipramine
Humans
Major depression
Male
Medical sciences
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
Psychiatric Status Rating Scales
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Side effects
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Summary:A sample of 120 patients, all of whom met DSM-III criteria for major unipolar depressive disorder, were randomly allocated to two treatment groups. Sixty patients were treated with fluoxetine and 60 with clomipramine during a 6-week period. No significant difference was found in antidepressant efficacy, with improvement occurring on both drugs. Important differences were found in the side-effects profile of each group, their incidence being significantly lower and tending to disappear during the course of treatment in the group of patients treated with fluoxetine.
ISSN:0165-0327
1573-2517
DOI:10.1016/0165-0327(91)90045-T