Responders and non-responders to drug treatment in social phobia: differences at baseline and prediction of response

Differences between responders and non-responders to drug therapy were investigated in social phobia. Two previously published studies were pooled to obtain data of 30 patients who were treated for 12 weeks with brofaromine or fluvoxamine. Four criterion variables were used to divide patients in res...

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Bibliographic Details
Published in:Journal of affective disorders 1996-06, Vol.39 (1), p.13-19
Main Authors: Slaap, Bernhard R., van Vliet, Irene M., Westenberg, Herman G.M., Den Boer, Johan A.
Format: Article
Language:English
Subjects:
Adult
Arousal - drug effects
Biological and medical sciences
Blood Pressure - drug effects
Double-Blind Method
Drug therapy
Female
Fluvoxamine - adverse effects
Fluvoxamine - therapeutic use
Heart rate
Heart Rate - drug effects
Humans
Male
Medical sciences
Middle Aged
Monoamine Oxidase Inhibitors - adverse effects
Monoamine Oxidase Inhibitors - therapeutic use
Neuropharmacology
Personality Inventory
Pharmacology. Drug treatments
Phobic Disorders - diagnosis
Phobic Disorders - drug therapy
Phobic Disorders - psychology
Piperidines - adverse effects
Piperidines - therapeutic use
Prediction of response
Prognosis
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Serotonin Uptake Inhibitors - adverse effects
Serotonin Uptake Inhibitors - therapeutic use
Social phobia
Treatment Outcome
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Description
Summary:Differences between responders and non-responders to drug therapy were investigated in social phobia. Two previously published studies were pooled to obtain data of 30 patients who were treated for 12 weeks with brofaromine or fluvoxamine. Four criterion variables were used to divide patients in responders and non-responders. Depending on the criterion variable up to 72% of the patients were regarded as responders. Non-responders differed from responders in that they had a higher heart rate and a higher blood pressure. They were also characterised by higher scores on several psychometric scales, indicative of illness severity.
ISSN:0165-0327
1573-2517
DOI:10.1016/0165-0327(96)00013-4