Effect of typical antipsychotic medications and clozapine on smooth pursuit performance in patients with schizophrenia

The effect of typical neuroleptic drugs or clozapine on smooth pursuit eye movements was tested in 13 patients with schizophrenia or schizoaffective disorder with a repeated measures design. Nineteen normal control subjects were also studied. Compared with controls, patients in the unmedicated state...

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Bibliographic Details
Published in:Psychiatry research 1992, Vol.41 (1), p.25-36
Main Authors: Friedman, Lee, Jesberger, John A., Meltzer, Herbert Y.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Antipsychotic Agents - adverse effects
Antipsychotic Agents - therapeutic use
Biological and medical sciences
Clozapine - adverse effects
Clozapine - therapeutic use
Dose-Response Relationship, Drug
Eye movements
Female
Hospitalization
Humans
Male
Medical sciences
neuroleptics
Neurologic Examination
Neuropharmacology
Pharmacology. Drug treatments
Psychiatric Status Rating Scales
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Psychotic Disorders - drug therapy
Psychotic Disorders - psychology
Pursuit, Smooth - drug effects
Saccades - drug effects
saccadic intrusions
Schizophrenia - drug therapy
Schizophrenic Psychology
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Summary:The effect of typical neuroleptic drugs or clozapine on smooth pursuit eye movements was tested in 13 patients with schizophrenia or schizoaffective disorder with a repeated measures design. Nineteen normal control subjects were also studied. Compared with controls, patients in the unmedicated state had low smooth pursuit gain, had a higher rate of corrective catch-up saccades, and tended to spend less time engaged in the tracking task. The patients did not significantly differ from controls on catch-up saccade amplitude, square wave jerk rate, or anticipatory saccade rate. Medication with clozapine, but not typical neuroleptics, was associated with an increase in median catch-up saccade amplitude. Number of days on clozapine and clozapine dose both correlated significantly with a worsening of oculomotor performance. No effect of medication with typical neuroleptics was found, although there was some evidence suggesting that such an effect may occur after more prolonged treatment.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(92)90015-U