Dopaminergic responsivity during cocaine abstinence: a pilot study

This preliminary study investigated dopamine (DA) function in six hospitalized cocaine-dependent subjects ( DSM-III-R) who received 1.5 mg/kg of active cocaine by mouth, t.i.d., for 3 days followed by 9 days of placebo cocaine. During early and late abstinence from cocaine, plasma growth hormone (GH...

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Bibliographic Details
Published in:Psychiatry research 1992-07, Vol.43 (1), p.77-85
Main Authors: McDougle, Christopher J., Price, Lawrence H., Palumbo, Joseph M., Kosten, Thomas R., Heninger, George R., Kleber, Herbert D.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Carbidopa
Cocaine - administration & dosage
Dopamine Agents
Drug addictions
Drug Combinations
Drug dependence
growth hormone
Growth Hormone - blood
homovanillic acid
Homovanillic Acid - blood
Humans
Levodopa
Male
Medical sciences
Methoxyhydroxyphenylglycol - blood
Middle Aged
Prolactin - blood
Receptors, Dopamine - physiology
Substance Withdrawal Syndrome - metabolism
Substance-Related Disorders - metabolism
Toxicology
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Summary:This preliminary study investigated dopamine (DA) function in six hospitalized cocaine-dependent subjects ( DSM-III-R) who received 1.5 mg/kg of active cocaine by mouth, t.i.d., for 3 days followed by 9 days of placebo cocaine. During early and late abstinence from cocaine, plasma growth hormone (GH), homovanillic acid (HVA), prolactin, and 3-methoxy-4-hydroxyphenethylene-glycol responses to the placebo-controlled administration of oral L-dopa 250 mg/carbidopa 25 mg (Sinemet®) were measured. Sinemet caused significantly greater placebo-corrected increases in GH and HVA during early as compared with late abstinence. Acute abstinence from cocaine may be associated with increased DA responsivity, which normalizes over time.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(92)90143-Q