Serotonergic ethanol effects and auditory evoked dipole activity in alcoholic and healthy subjects

Ethanol has central serotonergic effects that may be of pathogenetic importance in a subgroup of alcohol-dependent patients with a central serotonergic hypofunction. Recent results indicate that pronounced amplitude increases of auditory evoked responses (tangential dipoles, N 1/P 2 component) with...

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Bibliographic Details
Published in:Psychiatry research 1996-06, Vol.63 (1), p.47-55
Main Authors: Hegerl, Ulrich, Juckel, Georg, Schmidt, Lutz Günter, Rommelspacher, Hans
Format: Article
Language:English
Subjects:
Adult
Aged
Alcohol dependence
Alcohol Withdrawal Delirium - physiopathology
Alcohol Withdrawal Delirium - psychology
Alcoholic Intoxication - physiopathology
Alcoholic Intoxication - psychology
Alcoholic Intoxication - rehabilitation
Alcoholism - physiopathology
Alcoholism - psychology
Alcoholism - rehabilitation
Alcoholism and acute alcohol poisoning
Arousal - drug effects
Arousal - physiology
Biological and medical sciences
Biomarkers
Brain - drug effects
Brain - physiopathology
Brain Mapping
Carbohydrate deficient transferrin
Electroencephalography - drug effects
Ethanol - administration & dosage
Ethanol - pharmacokinetics
Evoked potentials
Evoked Potentials, Auditory - drug effects
Evoked Potentials, Auditory - physiology
Female
Humans
Male
Medical sciences
Middle Aged
Neurologic Examination
Receptors, Serotonin - drug effects
Receptors, Serotonin - physiology
Reference Values
Serotonin
Serotonin - physiology
Signal Processing, Computer-Assisted
Toxicology
Transferrin - analogs & derivatives
Transferrin - metabolism
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Summary:Ethanol has central serotonergic effects that may be of pathogenetic importance in a subgroup of alcohol-dependent patients with a central serotonergic hypofunction. Recent results indicate that pronounced amplitude increases of auditory evoked responses (tangential dipoles, N 1/P 2 component) with increasing stimulus intensity (loudness) may be an indicator of such a low serotonergic neurotransmission. Because of its serotonin-agonistic effects, ethanol can be expected to decrease this intensity dependence. Twenty-eight alcoholic patients were studied both in the intoxication phase and after 1 week of withdrawal. A reduced intensity dependence of the tangential dipole activity was observed in the intoxicated state. Correspondingly, a reduction of this parameter was found in 14 healthy subjects after an ethanol load (1 g/kg, p.o.).
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(96)02796-5