Study of chloroquine binding to melanins by pyrolysis-gas chromatography and electron spin resonance spectroscopy

Structural differences in melanins were studied by Curie-point pyrolysis-gas chromatography-mass spectrometry, electron spin resonance spectroscopy and chloroquine binding. Pyrolysis-gas chromatographic data on the polymer allow the calculation of a UU index that expresses the relative amount of uni...

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Bibliographic Details
Published in:Journal of analytical and applied pyrolysis 1986-07, Vol.9 (4), p.297-307
Main Authors: Stȩpień, Krystyna B., Dworzanski, Jacek P., Imielski, Stanisław, Wilczok, Tadeusz
Format: Article
Language:English
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Summary:Structural differences in melanins were studied by Curie-point pyrolysis-gas chromatography-mass spectrometry, electron spin resonance spectroscopy and chloroquine binding. Pyrolysis-gas chromatographic data on the polymer allow the calculation of a UU index that expresses the relative amount of unindolized DOPA-derived units in the melanins. It is shown that the content of unindolized units in the polymer depends strongly on the oxidation time and DOPA concentration used during the melanin synthesis. Comparison of the chloroquine binding to melanins and the pyrolysis data showed that there is an inverse relationship between the affinity of chloroquine and the UU index.
ISSN:0165-2370
1873-250X
DOI:10.1016/0165-2370(86)80003-1