Strong association of the third hypervariable region of HLA-DRβ1 with autism

We reported that the major histocompatibility complex (MHC) including the null allele of the C4B gene and the extended haplotype B44-C30-DR4 is associated with autism. We report now that the third hypervariable region (HVR-3) of certain DR β l alleles have very strong association with autism. The HV...

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Bibliographic Details
Published in:Journal of neuroimmunology 1996, Vol.67 (2), p.97-102
Main Authors: Warren, Reed P., Odell, J.Dennis, Warren, W.Louise, Burger, Roger A., Maciulis, Alma, Daniels, Wayne W., Torres, Anthony R.
Format: Article
Language:English
Subjects:
Autism
HLA-DR
Third hypervariable region
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Summary:We reported that the major histocompatibility complex (MHC) including the null allele of the C4B gene and the extended haplotype B44-C30-DR4 is associated with autism. We report now that the third hypervariable region (HVR-3) of certain DR β l alleles have very strong association with autism. The HVR-3 of DRβ1 ∗ 0401 or the shared HVR-3 alleles DR01 ∗ 0404 and DRβ1 ∗ 0101, was expressed on extended haplotypes in 23 of 50 (46%) autistic subjects as compared to only 6 of 79 (7.5%) normal subjects. Another HVR-3 sequence, the DRβ1 ∗ 0701 allele, was carried on extended haplotypes in 16 (32.0%) of the autistic subjects as compared to 8 (10.1 %) of the normal subjects.
ISSN:0165-5728
1872-8421
DOI:10.1016/0165-5728(96)00052-5