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The toxicology and metabolism of chlorothalonil in fish. I. Lethal levels for Salmo gairdneri, Galaxias maculatus, G. truttaceus and G. auratus and the fate of 14C-TCIN in S. gairdneri

LC 50 values of chlorothalonil (TCIN) to Salmo gairdneri, Galaxias maculatus, G. truttaceus and G. auratus for 24, 48 and 96 h were determined using a flow-through apparatus. All values were lower than those previously reported for various fish species. The influence of decreased oxygen concentratio...

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Bibliographic Details
Published in:Aquatic toxicology 1985-10, Vol.7 (1), p.93-105
Main Authors: Davies, P.E., White, R.W.G.
Format: Article
Language:English
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Summary:LC 50 values of chlorothalonil (TCIN) to Salmo gairdneri, Galaxias maculatus, G. truttaceus and G. auratus for 24, 48 and 96 h were determined using a flow-through apparatus. All values were lower than those previously reported for various fish species. The influence of decreased oxygen concentration and co-exposure of acephate on LC 50 values of TCIN to Salmo gairdneri was also investigated. Uptake of 14C-chlorothalonil in internal organs of Salmo gairdneri was measured during a 96 h exposure to 10 μg/l in water. The primary site of accumulation was the bile. Levels in all other organs were in the mg/kg range and increased with time of exposure. Protein binding was observed in the liver. Release of polar labelled metabolites was constant with time over 96 h depuration, with 0.5% being TCIN. All organ levels dropped during this time. The possible route of TCIN metabolism is discussed.
ISSN:0166-445X
1879-1514
DOI:10.1016/0166-445X(85)90038-4