Structure of the promoter for the human macrophage stimulating protein receptor gene

The macrophage stimulating protein receptor is a receptor protein tyrosine kinase of the met/hepatocyte growth factor receptor family. Binding of the macrophage stimulating protein to its receptor provokes changes in cell morphology and motility. Here we report the structure of the promoter of the g...

Full description

Saved in:
Bibliographic Details
Published in:Biochimica et biophysica acta 1995-07, Vol.1263 (1), p.93-95
Main Authors: Del Gatto, Fabienne, Gilbert, Emmanuelle, Ronsin, Christophe, Breathnach, Richard
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Base Sequence
Humans
Molecular Sequence Data
MSP
Promoter
Promoter Regions, Genetic
Receptor Protein-Tyrosine Kinases - genetics
Receptor, Macrophage Colony-Stimulating Factor - chemistry
Receptor, Macrophage Colony-Stimulating Factor - genetics
Ron
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The macrophage stimulating protein receptor is a receptor protein tyrosine kinase of the met/hepatocyte growth factor receptor family. Binding of the macrophage stimulating protein to its receptor provokes changes in cell morphology and motility. Here we report the structure of the promoter of the gene coding for this receptor. The major transcription start sites have been identified. The 5′ flanking region has characteristics of other receptor tyrosine kinase gene promoters, namely several GC boxes but the absence of a TATA box. Deletion analysis shows that multiple elements are needed for full promoter activity.
ISSN:0167-4781
0006-3002
1879-2634
DOI:10.1016/0167-4781(95)00082-R