Cloning and sequencing of a tpr-met oncogene cDNA isolated from MNNG-transformed human XP fibroblasts

A rearranged tpr-met oncogene was identified in a MNNG-transformed human Xeroderma pigmentosum (XP) cell line (ASKMN). A 2016 by cDNA was cloned and sequenced, disclosing an ORF with a coding capacity for a 523 as protein. The sequence of this tpr-met cDNA was very similar to that previously reporte...

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Bibliographic Details
Published in:Biochimica et biophysica acta 1995-12, Vol.1264 (3), p.254-256
Main Authors: Wicker, Rene, Bounacer, Ali, Gascon, Ana, Brison, Olivier, Sarasin, Alain, Suárez, Horacio G.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Base Sequence
c-met
cDNA cloning
cDNA sequencing
Cell Line, Transformed
Cloning, Molecular
DNA, Complementary - biosynthesis
DNA, Complementary - isolation & purification
Fibroblasts - drug effects
Fibroblasts - metabolism
HGF/SF
Humans
Methylnitronitrosoguanidine
MNNG, N-methyl- N′-nitro- N-nitrosoguanidine
Molecular Sequence Data
Oncogene Proteins, Fusion - genetics
Oncogenic activation
Rearrangement
Tyrosine-kinase receptor
XP, Xeroderma pigmentosum
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Summary:A rearranged tpr-met oncogene was identified in a MNNG-transformed human Xeroderma pigmentosum (XP) cell line (ASKMN). A 2016 by cDNA was cloned and sequenced, disclosing an ORF with a coding capacity for a 523 as protein. The sequence of this tpr-met cDNA was very similar to that previously reported in another human MNNG-transformed cell line (MNNG-HOS).
ISSN:0167-4781
0006-3002
1879-2634
DOI:10.1016/0167-4781(95)00174-3