Sequence and neuronal expression of mouse endothelin-1 cDNA

We have isolated and sequenced a cDNA that encodes mouse endothelin-1 (ET-1). The putative protein contains 202 amino acids corresponds to the prepro-form of ET-I. Twenty-one amino acids sequence of the putative mature ET-1 was identical with that of rat, porcine, bovine, and human. In situ hybridiz...

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Bibliographic Details
Published in:Biochimica et biophysica acta 1996-07, Vol.1307 (3), p.249-253
Main Authors: Kurama, Masae, Ishida, Norio, Matsui, Miwa, Saida, Kaname, Mitsui, Youji
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Cattle
cDNA
Clock
DNA, Complementary - chemistry
Endothelin
Endothelins - genetics
Humans
In Situ Hybridization
Mice
Molecular Sequence Data
Rats
RNA, Messenger - analysis
Suprachiasmatic nucleus
Suprachiasmatic Nucleus - metabolism
Swine
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Summary:We have isolated and sequenced a cDNA that encodes mouse endothelin-1 (ET-1). The putative protein contains 202 amino acids corresponds to the prepro-form of ET-I. Twenty-one amino acids sequence of the putative mature ET-1 was identical with that of rat, porcine, bovine, and human. In situ hybridization histochemistry indicate that ET-1 mRNA was expressed in several hypothalamic nuclei including the suprachiasmatic nucleus (SCN) in rodent brain.
ISSN:0167-4781
0006-3002
1879-2634
DOI:10.1016/0167-4781(96)00066-8