Molecular cloning of the cDNA encoding a helix-loop-helix protein, mouse ID1B: tissue-specific expression of ID1A and ID1B genes

A cDNA encoding a 168 amino acid mouse ID1B helix-loop-helix protein, the longest among the ID family of proteins so far identified, was cloned and its nucleotide sequence determined. Mouse ID1B mRNA is distinguishable from the mRNA encoding ID1A at its 3′ end, and the relative level of expression o...

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Bibliographic Details
Published in:Biochimica et biophysica acta 1996-07, Vol.1308 (1), p.28-30
Main Authors: Hernandez, Maria-Clemencia, Andres-Barquin, Pedro J., Israel, Mark A.
Format: Article
Language:English
Subjects:
Alternative Splicing
Amino Acid Sequence
Animals
Base Sequence
cDNA sequence
DNA, Complementary - genetics
Dominant-negative transcription factor
Genetic Variation
Helix-loop-helix
Helix-Loop-Helix Motifs
Inhibitor of Differentiation Protein 1
Mice
Molecular Sequence Data
Multigene Family
Repressor Proteins
Sequence Homology, Amino Acid
Species Specificity
Tissue Distribution
Transcription Factors - genetics
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Summary:A cDNA encoding a 168 amino acid mouse ID1B helix-loop-helix protein, the longest among the ID family of proteins so far identified, was cloned and its nucleotide sequence determined. Mouse ID1B mRNA is distinguishable from the mRNA encoding ID1A at its 3′ end, and the relative level of expression of these two different mRNAs is similar in most tissues, with exception of skeletal muscle and kidney. Comparison of the most carboxyl terminal predicted amino acid sequences of ID1 proteins reveals 100% identity for ID1A, but the predicted Id1B proteins of several species are different.
ISSN:0167-4781
0006-3002
1879-2634
DOI:10.1016/0167-4781(96)00092-9