Tolerance of nicotinamide and carbogen with radiation therapy for glioblastoma

Nineteen patients with glioblastoma were treated with nicotinamide and carbogen and radiotherapy. Eight patients did not complete the protocol because of hepatic toxicity from phenytoin/nicotinamide drug interactions, persistent nausea or vomiting with nicotinamide, intolerance of the carbogen breat...

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Bibliographic Details
Published in:Radiotherapy and oncology 1996-09, Vol.40 (3), p.245-247
Main Authors: Pickles, Tom, Graham, Peter, Syndikus, Isabel, Rheaume, Dorianne E., Duncan, Graeme G., Green, Alex, Marlow, Carol
Format: Article
Language:English
Subjects:
Administration, Inhalation
Administration, Oral
Adolescent
Adult
Aged
Animals
Carbogen
Carbon Dioxide - administration & dosage
Carbon Dioxide - adverse effects
Carbon Dioxide - therapeutic use
Combined Modality Therapy
Drug Tolerance
Female
Glioblastoma
Glioblastoma - diagnosis
Glioblastoma - drug therapy
Glioblastoma - radiotherapy
Humans
Liver - drug effects
Male
Middle Aged
Niacinamide - administration & dosage
Niacinamide - adverse effects
Niacinamide - therapeutic use
Nicotinamide
Oxygen - administration & dosage
Oxygen - adverse effects
Oxygen - therapeutic use
Prospective Studies
Radiation therapy
Radiotherapy Dosage
Rats
Treatment Outcome
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Description
Summary:Nineteen patients with glioblastoma were treated with nicotinamide and carbogen and radiotherapy. Eight patients did not complete the protocol because of hepatic toxicity from phenytoin/nicotinamide drug interactions, persistent nausea or vomiting with nicotinamide, intolerance of the carbogen breathing apparatus, or other reason. In addition, early radiation neurotoxicity appeared increased.
ISSN:0167-8140
1879-0887
DOI:10.1016/0167-8140(96)01792-6