Experimental determination of the effects of space charge on ion cyclotron resonance frequencies

In ion cyclotron resonance (ICR) and Fourier transform mass spectrometry (FTMS) the mass-to-charge ratio of an ion is calculated from its measured cyclotron frequency. In principle this can be done very accurately because frequency is a physical parameter that can be measured to sub-p.p.m. accuracy...

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Bibliographic Details
Published in:International journal of mass spectrometry and ion processes 1983-10, Vol.54 (1), p.189-199
Main Authors: Francl, Thomas J., Sherman, Michael G., Hunter, Richard L., Locke, Michael J., Bowers, William D., McIver, Robert T.
Format: Article
Language:English
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Summary:In ion cyclotron resonance (ICR) and Fourier transform mass spectrometry (FTMS) the mass-to-charge ratio of an ion is calculated from its measured cyclotron frequency. In principle this can be done very accurately because frequency is a physical parameter that can be measured to sub-p.p.m. accuracy using standard laboratory equipment. In this paper the factors which limit mass measurement accuracy in FTMS and ICR will be discussed in the framework of a theoretical model for the ion space-charge effects derived in the previous paper. The resulting calibration procedure gives accurate mass determinations with errors of less than 1 p.p.m.
ISSN:0168-1176
1873-2801
DOI:10.1016/0168-1176(83)85017-4