Comparison of energy-resolved low-energy CAD of stable and isomerizing ions in an FT-ICR and in other tandem mass spectrometers

• Published in: International journal of mass spectrometry and ion processes 1994-02, Vol.130 (3), p.187-205
• Main Authors: Stirk, Krista M., Lin, Peiping, Ranatunga, Thilini D., Zeller, Loreen C., Farrell, John T., Kenttämaa, Hilkka I.
• Format: Article
• Language: English
• Subjects: Chemistry; Collision activated dissociation; Energy resolved mass spectrometry; Exact sciences and technology; Fourier transform ion cyclotron resonance; Ion trap; Isomerization; Mass spectrometry; Organic chemistry; Reactivity and mechanisms
• ISSN: 0168-1176; 1873-2801
• DOI: 10.1016/0168-1176(94)85015-1

Energy-resolved collisionally-activated dissociation (CAD) was carried out in a dual-cell FT-ICR for the molecular ions of n-propanol, hexafluoropropene, three ionized organophosphorus esters, and four C 3H 7O + isomers. The results are compared to data measured earlier in triple quadrupole, BQQ, BEQQ, and quadrupole ion trap mass spectrometers. In general, low-energy CAD spectra generated in a dual-cell FT-ICR are comparable to those measured using other types of tandem mass spectrometers when roughly similar activation conditions are used (number of activating collisions, laboratory ion kinetic energy), and this agreement is best at low collision energies. However, ions which undergo slow isomerization prior to collisional activation are an exception. These ions can yield CAD product distributions in an FT-ICR and other ion traps that are significantly different from those obtained in mass spectrometers which sample ions with shorter lifetimes.