Physicochemical aspects of controlled release of substituted benzoic and naphthoic acids from Carbopol® gels

Drug release from a matrix consisting of a physical mixture of Carbopol and a weak acid is dependent on the influence of the physicochemical properties of the drug on gel formation in the matrix. Water hydrates the polymer in the matrix which results in swelling and the formation of a gel layer. The...

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Bibliographic Details
Published in:Journal of controlled release 1995-12, Vol.37 (3), p.281-289
Main Authors: French, Donna L., Himmelstein, Kenneth J., Mauger, John W.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carbopol
Gel formation
General pharmacology
Medical sciences
Microenvironmental pH
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymeric matrix
Substituted benzoic acid
Substituted naphthoic acid
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Summary:Drug release from a matrix consisting of a physical mixture of Carbopol and a weak acid is dependent on the influence of the physicochemical properties of the drug on gel formation in the matrix. Water hydrates the polymer in the matrix which results in swelling and the formation of a gel layer. The solubility and ionization properties of the dissolving drug influence the thickness and viscosity of the gel layer. In turn, the properties of the gel layer affect drug release rate by influencing drug diffusivity and the diffusional pathlength. Examination of the physicochemical properties of the drug is an important factor in elucidating the mechanism of release from Carbopol gels.
ISSN:0168-3659
1873-4995
DOI:10.1016/0168-3659(95)00086-0