Enhanced skin permeation of diclofenac by iontophoresis: in vitro and in vivo studies

In vitro and in vivo iontophoretic studies were conducted on diclofenac sodium solution, diclofenac diethylammonium solution and Voveran Gel® and enhanced permeation across rat skin was achieved as compared to passive diffusion. A 50% increase in drug permeation was obtained in the in-vitro release...

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Bibliographic Details
Published in:Journal of controlled release 1996, Vol.38 (1), p.21-27
Main Authors: Varghese, Elizabeth, Khar, R.K.
Format: Article
Language:English
Subjects:
Anti-inflammatory
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Diclofenac
Iontophoresis
Medical sciences
Pharmacology. Drug treatments
Skin permeation
Transdermal
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Summary:In vitro and in vivo iontophoretic studies were conducted on diclofenac sodium solution, diclofenac diethylammonium solution and Voveran Gel® and enhanced permeation across rat skin was achieved as compared to passive diffusion. A 50% increase in drug permeation was obtained in the in-vitro release studies while a nearly 20% increase in inhibition of oedema was obtained for different formulations of diclofenac in vivo. A linear correlation was found between the log dose and response, validating the bioassay method used in this study.
ISSN:0168-3659
1873-4995
DOI:10.1016/0168-3659(95)00095-X