Weakness of mucosal barrier in portal hypertensive gastropathy of alcoholic cirrhosis. Effects of propranolol and enprostil

Background/Aims: It has been suggested that the vulnerability of gastric mucosa is increased in patients with cirrhosis as a result of a PGE2 deficiency. Therefore, we evaluated whether PGE2 mucosal generation, and gastric potential difference - a reflection of the gastric mucosal barrier - were cor...

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Bibliographic Details
Published in:Journal of hepatology 1995-12, Vol.23 (6), p.689-696
Main Authors: Payen, Jean-Louis, Cales, Paul, Pienkowski, Patrice, Sozzani, Patricia, Kervran, Alain, Frexinos, jacques, Pascal, Jean-Pierre
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - pharmacology
Adult
Aged
Anti-Ulcer Agents - pharmacology
Aspirin
Aspirin - adverse effects
Cirrhosis
Dinoprostone - physiology
Enprostil - pharmacology
Female
Gastric Mucosa - drug effects
Gastric Mucosa - physiopathology
Gastrin
Gastrins - blood
Gastrotoxicity
Glucagon
Humans
Hypertension, Portal - complications
Hypertension, Portal - physiopathology
Liver Cirrhosis, Alcoholic - physiopathology
Male
Middle Aged
PGE2
Portal hypertension
Portal hypertensive gastropathy
Potential difference
Propranolol - pharmacology
Stomach
Stomach Diseases - physiopathology
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Summary:Background/Aims: It has been suggested that the vulnerability of gastric mucosa is increased in patients with cirrhosis as a result of a PGE2 deficiency. Therefore, we evaluated whether PGE2 mucosal generation, and gastric potential difference - a reflection of the gastric mucosal barrier - were correlated to endoscopic features and whether these alterations could be alleviated. Methods: The potential difference was measured before (basal) and after a stimulation test by aspirin. The serum levels of gastrin and glucagon were also determined. Finally, the effects of a 1-week administration of propranolol or enprostil were tested on potential difference. The endoscopic grade of portal hypertensive gastropathy was assessed according to McCormack et al. The results are presented respectively for controls, patients with mild gastropathy, and patients with severe gastropathy. Comparisons were made using variance or covariance analysis after adjustment with age. Results: Basal potential difference was significantly different betweeen the three groups: −30.6, −28.8, t-24.9 mV, p
ISSN:0168-8278
1600-0641
DOI:10.1016/0168-8278(95)80035-2