Bis-naphthalimides. 2. Synthesis and biological activity of 5,6-acenaphthalimidoalkyl-1,8-naphthalimidoalkyl amines

A series of non-symmetric bis-naphthalimides bearing a conveniently substituted 1,8-naphthalimide and a 5,6-acenaphthalimide chromophore was synthesized and in vitro activities were determined. Although previous studies suggested that the presence of the acenaphthalimide system in the structure enha...

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Bibliographic Details
Published in:European journal of medicinal chemistry 1995, Vol.30 (3), p.235-239
Main Authors: Braña, MF, Castellano, JM, Morán, M, Pérez de Vega, MJ, Qian, XD, Romerdahl, CA, Keilhauer, G
Format: Article
Language:English
Subjects:
bis-intercalator
bis-naphthalimide
cancer
naphthalimide
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Summary:A series of non-symmetric bis-naphthalimides bearing a conveniently substituted 1,8-naphthalimide and a 5,6-acenaphthalimide chromophore was synthesized and in vitro activities were determined. Although previous studies suggested that the presence of the acenaphthalimide system in the structure enhances aqueous solubility, we found that these compounds were no more soluble or cytotoxic than the homologous symmetric series.
ISSN:0223-5234
1768-3254
DOI:10.1016/0223-5234(96)88230-4