Implantable glucose sensors: Choosing the appropriate sensing strategy

The special requirements for implantable glucose sensors which differ from laboratory analysers and in vitro probes include continuous operation without drift, compatibility with in vivo body conditions, electrical and toxicological safety and patient acceptability. We have studied the effect of oxy...

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Bibliographic Details
Published in:Biosensors 1987, Vol.3 (6), p.335-346
Main Authors: Pickup, John C., Shaw, Gill W., Claremont, Denzil J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biosensing Techniques
Biotechnology
Blood Glucose - analysis
Diabetes mellitus
Diabetes Mellitus, Type 1 - blood
enzyme electrode
Enzyme engineering
ferrocene
Ferrous Compounds
Fundamental and applied biological sciences. Psychology
glucose sensor
Humans
Hydrogen-Ion Concentration
Methods. Procedures. Technologies
Miscellaneous
Organometallic Compounds
Oxygen - blood
Prostheses and Implants
Temperature
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Summary:The special requirements for implantable glucose sensors which differ from laboratory analysers and in vitro probes include continuous operation without drift, compatibility with in vivo body conditions, electrical and toxicological safety and patient acceptability. We have studied the effect of oxygen tension, operating temperature and pH, and the stability of various potentially implantable amperometric glucose sensors so as to aid the choice of the technologies most suitable for in vivo application.
ISSN:0265-928X
DOI:10.1016/0265-928X(87)80016-0