The integrated antioxidant system

The diversity and depth of the body's antioxidant protection system is reviewed. Components of both endogenous and exogenous origins contribute protection, and new data suggests that some components interact to spare or replace each other. Evidence from both animal and human studies shows that...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition Research 1995-05, Vol.15 (5), p.755-766
Main Author: Jacob, Robert A.
Format: Article
Language:English
Subjects:
ACIDE ASCORBIQUE
ACIDO ASCORBICO
ANTIOXIDANTES
Antioxidants
ANTIOXYDANT
DANOS
DEGAT
DIETA
Free radicals
GLUTATHION
GLUTATION
INTERACCIONES NUTRIENTE NUTRIENTE
INTERACTION NUTRIMENT NUTRIMENT
MINERALES
MINERAUX
OXIDACION
Oxidative damage
OXYDATION
RADICAL LIBRE
RADICALES LIBRES
REGIME ALIMENTAIRE
VITAMINA E
VITAMINE E
Vitamins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The diversity and depth of the body's antioxidant protection system is reviewed. Components of both endogenous and exogenous origins contribute protection, and new data suggests that some components interact to spare or replace each other. Evidence from both animal and human studies shows that glutathione and vitamin C can act in concert to alleviate a variety of oxidant stresses. Results from in vitro and animal studies indicate that vitamin C regenerates tocopherol in the lipid phase, but this interaction has not yet been shown to be important to human nutrition and metabolism. Newer evidence suggests that β-carotene and tocopherol may act synergistically against lipid peroxidation, and that polyphenols, such as flavonoids provide antioxidant protection which is enhanced by vitamin C. The diverse roles of iron and copper in redox biochemistry is illustrated by their incorporation in protective metalloenzymes and by some proposed interactions with vitamins. The emerging picture of synergisms and interactions suggests that antioxidant protection may be more flexible and efficient than indicated by studies of single nutrient effects. The apparent versatility of the oxidant defense system implys that it is capable of taking advantage of diverse antioxidants provided by the diet, as well as excesses of a particular antioxidant nutrient.
ISSN:0271-5317
1879-0739
DOI:10.1016/0271-5317(95)00041-G