Dietary vitamin A deficiency and the immune system in a murine model of systemic lupus erythematosus

The purpose of this study was to investigate the effects of dietary vitamin A deficiency on the onset and progression of systemic lupus erythematosus (SLE), a severe autoimmune disorder, using the murine SLE model, MRL MPJ - lpr lpr ( MRL l ) mice. Sixty weanling female 4-week old MRL lpr mice were...

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Bibliographic Details
Published in:Nutrition research (New York, N.Y.) N.Y.), 1996-02, Vol.16 (2), p.279-292
Main Authors: Liao, C.Hua, Erdman, J.W., Voss, E.W., Johnston, P.V.
Format: Article
Language:English
Subjects:
[formula omitted] mouse
Biological and medical sciences
Medical sciences
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
SLE
Vitamin A deficiency
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Summary:The purpose of this study was to investigate the effects of dietary vitamin A deficiency on the onset and progression of systemic lupus erythematosus (SLE), a severe autoimmune disorder, using the murine SLE model, MRL MPJ - lpr lpr ( MRL l ) mice. Sixty weanling female 4-week old MRL lpr mice were randomly assigned to either the vitamin A-deficient (A −), A-sufficient (A +), and A-sufficient diet/feed restricted (DR) groups. The weight losses due to the onset of SLE for both the A+ and the DR groups were greater than that for the A- group (P
ISSN:0271-5317
1879-0739
DOI:10.1016/0271-5317(96)00012-7