Use of tissue slices in chemical mixture toxicology and interspecies investigations

Precision-cut tissue slices have proven to be a useful in vitro system for biotransformation and toxicity studies. Since tissue slices can be readily prepared from a variety of tissues and species, they can easily be used for interspecies investigations and comparisons. Furthermore, slices can be re...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 1995-12, Vol.105 (2), p.285-290
Main Authors: Gandolfi, A.Jay, Brendel, Klaus, Fisher, Robyn L., Michaud, John-Pierre
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biotransformation
Bromobenzenes - toxicity
Chlorobenzenes - toxicity
Drug Interactions
General aspects. Methods
Hazardous Substances - metabolism
Hazardous Substances - toxicity
Humans
In Vitro Techniques
Interactions
Interspecies
Intracellular Fluid - chemistry
Liver - pathology
Medical sciences
Microtomy
Mixtures
Potassium - analysis
Rats
Rats, Inbred F344
Rats, Sprague-Dawley
Species Specificity
Tissue slices
Toxicology
Xenobiotics - metabolism
Xenobiotics - toxicity
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Summary:Precision-cut tissue slices have proven to be a useful in vitro system for biotransformation and toxicity studies. Since tissue slices can be readily prepared from a variety of tissues and species, they can easily be used for interspecies investigations and comparisons. Furthermore, slices can be readily prepared from human tissue, thus comparisons (extrapolation) can be made between laboratory animals and humans. Slices can also be used to examine the toxic interactions of chemicals in vitro. It is important to use the correct experimental design to demonstrate toxic interactions and to assure that the tissue slices are properly exposed to the chemicals. Overall, tissue slices offer a valid in vitro system for performing species comparisons and chemical-chemical interaction studies.
ISSN:0300-483X
1879-3185
DOI:10.1016/0300-483X(95)03224-4