Lipid peroxidation and brain mitochondrial damage induced by ethanol

An acute ethanol load (50 mmol/kg, i.p.) results in an increase in lipid peroxidation and a decrease in the levels of vitamins C and E in rat cerebellum. The decrease in vitamin E is prevented by allopurinol administration. These results suggest that acute ethanol load induces an oxidative stress at...

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Bibliographic Details
Published in:Bioelectrochemistry and Bioenergetics 1987-12, Vol.18 (1), p.211-217
Main Authors: Rouach, H., Ribiere, C., Park, M.K., Saffar, C., Nordmann, R.
Format: Article
Language:English
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Summary:An acute ethanol load (50 mmol/kg, i.p.) results in an increase in lipid peroxidation and a decrease in the levels of vitamins C and E in rat cerebellum. The decrease in vitamin E is prevented by allopurinol administration. These results suggest that acute ethanol load induces an oxidative stress at the cerebellar level. Brain mitochondrial superoxide production is, however, unchanged. Moreover, the brain mitochondria of such ethanol-treated rats are characterized by a marked inhibition of state 3 respiratory activity.
ISSN:0302-4598
DOI:10.1016/0302-4598(87)85023-7