Interfacial behaviour of trideoxyribonucleotide d(CpGpG) and its complex with the antitumour drug cis platin at the mercury/electrolyte solution interface

The adsorption of the trideoxyribonucleotide diphosphate d(CpGpG) and its complex with cis-DDP at the dropping mercury electrode was investigated by measurement of differential capacitance of the electric double layer. It was found that non-platinated trimer yields an anomalous pit on the capacitanc...

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Bibliographic Details
Published in:Bioelectrochemistry and Bioenergetics 1989, Vol.21 (2), p.199-204
Main Authors: Brabec, V., Vetterl, V., Kleinwächter, V., Reedijk, J.
Format: Article
Language:English
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Summary:The adsorption of the trideoxyribonucleotide diphosphate d(CpGpG) and its complex with cis-DDP at the dropping mercury electrode was investigated by measurement of differential capacitance of the electric double layer. It was found that non-platinated trimer yields an anomalous pit on the capacitance curves at higher bulk concentrations. On the other hand, the platinated trinucleotide does not yield the pit under the same experimental conditions. It was suggested that the compact and perpendicular adsorption film, responsible for the formation of the anomalous pit on the capacitance curves, does not appear if the stacking interactions between parallel base rings are disturbed.
ISSN:0302-4598
DOI:10.1016/0302-4598(89)80007-8