Synergistic induction of apoptosis in breast cancer cells by tamoxifen and calmodulin inhibitors

Breast cancer cells are relatively resistant to the induction of apoptosis (AP) and drug regimens which readily activate apoptotic death, may enhance the antitumor effect. Rapid and intensive induction of apoptosis was observed in estrogen receptor positive and negative breast cancer cell cultures t...

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Bibliographic Details
Published in:Cancer letters 1995-11, Vol.97 (2), p.149-154
Main Authors: Frankfurt, Oskar S., Sugarbaker, Everett V., Robb, James A., Villa, Luis
Format: Article
Language:English
Subjects:
Antineoplastic agents
Apoptosis
Apoptosis - drug effects
Biological and medical sciences
Breast cancer
Breast Neoplasms - pathology
Calmodulin - antagonists & inhibitors
Calmodulin inhibitors
Chemotherapy
Drug Synergism
Estrogen Antagonists - pharmacology
Female
Humans
Medical sciences
Pharmacology. Drug treatments
Tamoxifen
Tamoxifen - pharmacology
Trifluoperazine - pharmacology
Tumor Cells, Cultured
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Summary:Breast cancer cells are relatively resistant to the induction of apoptosis (AP) and drug regimens which readily activate apoptotic death, may enhance the antitumor effect. Rapid and intensive induction of apoptosis was observed in estrogen receptor positive and negative breast cancer cell cultures treated with tamoxifen (TMX) combined with the calmodulin antagonists trifluoperazine (TFP) or W7. TMX (1–5μM) alone or calmodulin antagonists alone did not induce apoptosis. Importantly, intensive apoptosis was also induced by TMX and TFP in the cells obtained from primary human breast carcinomas. Inhibition of the Ca 2+ calmodulin signaling pathway is an effective way to activate apoptotic death in epithelial cells. Combination of TMX with non-toxic calmodulin inhibitors may increase the preventive and therapeutic effects of TMX.
ISSN:0304-3835
1872-7980
DOI:10.1016/0304-3835(95)03970-8